DMSO: The Real Miracle Solution

Due to the nuclear alert in Japan and its likelihood to affect the United States and other parts of the world, I decided to carry this article which I wrote for the Dot Connector Magazine‘s issue N. 12.

First, a little bit of background.

Radiation produces free-radicals (“inflammatory molecules”) that damage cells that make up tissues such as organs, glands, muscles, and bones. Besides causing the cells to age more quickly they also become distorted, or mutated, creating cancers such as leukemia, anemia, birth defects, and other diseases.

Sulfur has a long history of use as an antidote for acute exposure to radioactive material. DMSO is the classical sulfur compound. A Japanese study showed that even low concentrations of DMSO had radio-protective effects through the facilitation of DNA double-strand break repair, providing protection against radiation damage at all cellular levels in the whole body.

Remember that boosting your body’s detox capabilities and overall anti-oxidants levels is a key to survive in these stressful times. Being on a detox diet is crucial to regain health in a toxic environment. Our extensive experience and research shows that those on a no grain/low carb (no gluten) and non dairy diet fare MUCH better.

For more information on how to protect yourself from nuclear radiation, see:

Treatments for Nuclear Contamination

Iodine Treatments for Radiation Exposure

Greenmedinfo.com – Radioprotective

DMSO is an effective pain killer, blocking nerve conduction fibers that produce pain. It reduces inflammation and swelling by reducing inflammatory chemicals. It improves blood supply to an area of injury by dilating blood vessels and increasing delivery of oxygen and by reducing blood platelet stickiness. It stimulates healing, which is a key to its usefulness in any condition. It is among the most potent free radical scavengers known to man, if not the most potent one.

In 1866, Russian scientist Alexander Saytzeff isolated a most curious and peculiar chemical compound. It was crystalline, odor-less, non-toxic and had a garlic-like taste when consumed. At the time, Saytzeff had no way to predict that his discovery was going to prove highly controversial throughout its entire medical history, that it was going to be tested in thousands of studies, providing miraculous relief in numerous patients.

I’m talking here about dimethyl sulfoxide (DMSO), an organic sulfur compound which was used only as an industrial solvent, that is, until its medical properties were discovered in 1963 by a research team headed by Stanley W. Jacob, MD.
DMSO is a by-product of kraft pulping (the “sulfate process”) which converts wood into wood pulp consisting of almost pure cellulose fibers. As industrial as it may sound, the process simply entails a treatment of wood chips with a mixture of sodium hydroxide and sodium sulfide, known as white liquor, breaking the bonds which link lignin (from the Latin word lignum, meaning wood) to the cellulose.

DMSO is useful as a pain reliever, in burns, acne, arthritis, mental retardation, strokes, amyloidosis, head injury, scleroderma, it soothes toothaches, eases headaches, hemorroids, muscle strains, it prevents paralysis from spinal-chord injuries, it softens scar tissues. In fact, it is useful in well over 300 ailments and it is safe to use. You would think that a compound that has so many alleged uses and benefits will be automatically suspect, but careful examination of its properties and the data available will shed some light in this miraculous chemical.

Sulfur: The Stuff of Life

DMSO is an intermediate product of the global Sulfur Cycle which distributes bioavailable sulfur for all animal and plant life (Parcell, 2002). Sulfur compounds are found in all body cells and are indispensable for life, they are needed for a number of chemical reactions involved in the detoxification of drugs and other harmful toxins, and they have potential clinical applications in the treatment of a number of conditions such as depression, fibromyalgia, arthritis, intersticial cystitis, athletic injuries, congestive heart failure, diabetes, cancer, and AIDS (Parcell, 2002). Among the sulfur compounds, DMSO is probably the one that has the widest range and greatest number of therapeutic applications ever shown for any other single chemical. It has around 40 pharmacological properties that may be beneficial in the prevention, relief or reversal of numerous diseases (Morton, 1993).

Someone complained to Dr. Jacob of a splitting headache and gave him permission to apply some DMSO after hearing of its capabilities. The headache was gone in minutes, came back in four hours, and left for good after DMSO was applied a second time. Used for one purpose, sometimes it did another; put on a cold sore, within a few hours it cleared up a woman’s sinusitis. A woman who had had a stroke found after DMSO was painted on her painful jaw that she could now write with her paralyzed hand and could walk better. (Haley, 2000)

Therapeutic Properties

DMSO is an effective pain killer, blocking nerve conduction fibers that produce pain. It reduces inflammation and swelling by reducing inflammatory chemicals. It improves blood supply to an area of injury by dilating blood vessels and increasing delivery of oxygen and by reducing blood platelet stickiness. It stimulates healing, which is a key to its usefulness in any condition. It is among the most potent free radical scavengers known to man, if not the most potent one. This is a crucial mechanism since some molecules in our bodies produce an unequal number of electrons and the instability of the number causes them to destroy other cells. DMSO hooks on to those molecules and they are then expelled from the body with the DMSO.

 

 

Dr Stanley Jacob working with DMSO in the 1960s


DMSO also penetrates the skin and the blood-brain barrier with ease, penetrating tissues, and entering the bloodstream. Furthermore, DMSO protects the cells from mechanical damage and less of it is needed to achieve results as time passes as oppossed to most pharmaceuticals where increasing doses are required. It has a calming effect in the central nervous system and it reaches all areas of the body, when absorbed through the skin, including the brain. That is, DMSO applied to one area often leads to pain relief in some other location due to its systemic effect.

It acts as a carrier for other substances or drugs and it also potentiates their effect. In fact, certain drugs dissolved in DMSO, such as corticoids, antibiotics and insulin, may be used in a lower dose than usual without reducing their therapeutic efficacy and in addition, their undesirable side effects are greatly diminished. Also, drugs are able to pass through the blood-brain barrier which is usually impenetrable.

DMSO promotes the excretion of urine and functions as a muscle relaxant. It boosts the immune system, increasing the production of white cells and macrophages that destroy foreign material and pathogens in the body. It also has anti-bacterial, anti-viral and anti-fungal properties. DMSO also increases the permeability of cell membranes, allowing a flushing of toxins from the cell.

DMSO has radioprotective properties against lethal and mutagenic effects of X-rays in cells, cellular systems and whole animals. It also has cryoprotective properties, meaning that it is capable of protecting against injury due to freezing.
DMSO has also been shown to have cholinesterase properties (Sams, 1967), in other words, it inhibits an enzyme from breaking down acetylcholine, increasing both the level and duration of action of this important neurotransmitter. Acetylcholine is responsible for learning and memory and is also calming and relaxing. Acetylcholine is also a major factor in regulating the immune system, acting as a major brake on inflammation in the body.

As a source of sulfur, DMSO aids in heavy metal detoxification. Sulfur binds with toxic heavy metals (mercury, lead, aluminum, cadmium, arsenic, nickel) and eliminates them via urination, defecation and sweating.

FDA and Big Pharma Obstacles

DMSO is sold in health food stores, mail-order outlets, on the Internet, and in most countries around the world. It is used by millions for its health benefits yet in the U.S., DMSO has FDA approval only as a preservative of stem cells, bone marrow cells, and organs for transplant, and for interstitial cystitis – a painful inflammatory condition of the bladder which is very difficult to treat with other therapies.

That DMSO has not found favor as a remedy for other medical conditions is partly due to the inability to test it in double-blind experiments. Blind studies, as the name suggests, requires that a study be done without knowing which patient is taking the placebo or the drug. In the case of the DMSO, a blind study is impossible since the peculiar garlic-like taste and smell (no matter the route of application) gives it away and no satisfactory placebo could be devised that would mimic this particular effect of DMSO (Steinberg, 1967).

The FDA and big pharma would prefer we remain dependent on their drugs.


If you search for DMSO on the U.S. National Library of Medicine (pubmed.gov), you’ll get almost 30,000 indexed results, making it one of the most studied compounds of our time. Yet, we are led to believe that DMSO can’t pass the required regulations for its approval in other medical conditions even though its effectiveness and low toxicity profile is unquestionable.

You see, DMSO is a common chemical that can be manufactured cheaply. No drug company can get an exclusive patent since it is also a natural compound, therefore there is no significant financial return. In fact, an executive of a major drug company is quoted as saying, “I don’t care if DMSO is the major drug of our century and we all know it is, it isn’t worth it to us” [CBS TV show 60 minutes with Mike Wallace, The Riddle of DMSO]. If DMSO were to be approved by the FDA, it would be competetive and drug companies would be unable to hold the patents. In the words of the director of the Bureau of Drugs of the FDA, J. Richard Crout, M.D., “DMSO is a low toxicity and safe compound (…) I think that it is a fact of life that drug companies are not going to invest in something unless they think there is some financial return” [CBS TV show 60 minutes with Mike Wallace, The Riddle of DMSO].

Despite restrictions on the use of DMSO, thousands of Americans purchase it on the ‘black market’ each year, its popularity due not to publicity, but rather ‘word of mouth’. When you have something that relieves all kinds of ailments, including some life-threatening ones, people naturally recommend it to friends and family!

In Perspective

In the 1960s, research with DMSO on humans was temporarily halted after certain animals treated with DMSO were found to have changes in the eye lens. Some of these changes resembled those seen in aging dogs (Gordon, 1967), but nevertheless, research was gradually restarted after no evidence was found of eye changes in humans. As Daniel Haley reports in his book Politics in Healing: “Tests in rabbits, dogs, and pigs (but not humans) had shown some problems. When quantities of DMSO equal to about ten times the maximum human dose were given every day over a period of six months, slight changes in the lenses of the animals’ eyes would result, enough to produce a slight nearsightedness. The lens changes were not enough to cause dogs difficulty when running – they didn’t bump into things – and in some cases, the changes disappeared after the massive DMSO doses were stopped. In no test at that time or since has DMSO ever caused cataracts, either in animals or in humans” (Haley, 2000).

In fact, DMSO is effective for macular degeneration and retinal disease, both diseases of the eye. This effectiveness was first discovered when patients with retinitis pigmentosa, a retinal disease, were taking DMSO for certain musculoskeleteal disorders. They sensed that their vision had improved and some had remarkable results (Morton, 1993).

As far as eyes are concerned, the evidence on DMSO is quite to the contrary. When several patients treated with DMSO for muscular problems reported to Dr. Jacob that their vision had improved, he sent them to Dr. Robert O. Hill, ophthalmologist at the University of Oregon Medical School. Confirming the favorable changes, Dr. Hill began his own experiments with DMSO (after it was known that the lens changes did not happen in humans). His research showed drops of 50% DMSO to be effective in retinitis pigmentosa and macular degeneration, and presented a report on this at the New York Academy of Sciences symposium in 1971. (Haley, 2000)

In contrast, the number of medication-related deaths in the U.S. is estimated at over 200,000 a year, making medications the third or fourth leading cause of death (Pezzalla, 2005). Even common pain relievers called NSAIDs, examples of which include Advil, Motrin, Aleve and aspirin, account for an estimated 7,600 deaths and 76,000 hospitalizations in the U.S. every year (Tamblyn et al, 1997). Taking this into consideration, it is safe to declare that DMSO is among the safest substances in the world today. In fact, the classic test for toxicity -the LD-50 test – measures the lethal dose (LD) at which half of a group of test animals is killed. The LD-50 tests for aspirin and DMSO show that aspirin is seven times more toxic than DMSO (Haley, 2000).

Quick Guide and Ailments

DMSO is generally applied to the skin in a gel, cream, or liquid. It can be taken by mouth or as an intravenous injection, in many cases along with other drugs. It has also been administered subcutaneously, intramuscularly, intraperitoneally, intrathecally, by inhalation, instilled into the eye, on the mucous membranes, and into the urinary bladder. Strenghs and dosages vary widely.
If you are just dealing with pain or an injury, use a topical application. Don’t drink it. Drinking it is for serious detoxing and other internal necessities. If you use a rose scented DMSO cream, chances are that nobody will be able to smell DMSO’s garlic-like smell.

DMSO being distilled.

 

The usual oral dose of DMSO is one teaspoon per day of DMSO 70% (Morton, 1993). But since it can trigger detoxification reactions and DMSO’s total excretion from the body can take several days, it is best to do it only once a week. Start with half a teaspoon of DMSO 50% and increase to a teaspoon of DMSO 70% only if any possible detoxification reaction is well tolerated.

When you use liquid DMSO in the skin, let it dry for over 20 to 30 minutes before wiping the rest out. The skin must be clean, dry, and unbroken for any topical use of DMSO. The face and the neck are more sensitive to DMSO and no higher concenrations than 50% should be applied there. Topical concentrations of DMSO should be kept below 70% in areas where there is a reduction of circulation. When 60 to 90% DMSO is applied to the skin, warmth, redness, itching, and somtimes local hives may occur. This usually disappears within a couple of hours and using natural aloe vera, gel or cream, will help counteract or prevent this effect. When 60 to 90% DMSO is applied to the palm on the hand, the skin may wrinkle and stay that way for several days.

“My brother put some DMSO gel (70% dmso, 30% aloe vera) on his shoulders and lower part of neck because he had muscle pain/soreness in that area, and it caused skin redness/irritation for a few hours, although it did diminish the muscle soreness as well…my grandma has rheumatoid arthritis that made her legs swell up and hurt continuously, and I had her apply the same DMSO gel, and after about 2-3 days of applying it once a day, the swelling was 90% gone, and I think within 4-5 days it was 100% gone, and she said the pain diminished as well.” – Michael Shatskiy, Los Angeles, California, United States

Chronic pain patients often have to apply the substance for 6 weeks before a change occurs, but many report relief to a degree that had not been able to obtain from any other source. In general, the greater the chronicity of the disorder, the longer the treatment with DMSO must be employed in order to achieve palliation (Steinberg , 1967).

Common health problems for which people will apply topical DMSO at home include acute musculoskeletal injuries and inflammations. The earlier DMSO is used, the more dramatic the result. A 70% concentration of DMSO mixed with water in volumes ranging from 8 to 12 ml, applied on and around the injury in a wide area at least three times daily, will have a healing affect in 4 out ot 5 people.

Arthritis, Sprains, Strains

It provides rapid amelioriation of pain and increased mobility and reduction of inflammation when used topically. You can see a positive response within 5 to 20 minutes and usually lasting for 4 to 6 hours. (Steinberg, 1967).

“Applying DMSO where it hurt to a six-year-old wasted from rheumatoid arthritis, in a half hour the child could move her shoulder and turn her head for the first time in two years. Persuaded to try walking, she managed a few steps and then burst into tears. “Why are you crying?” Dr Jacob asked her. “Because it doesn’t hurt anymore”, she replied. (Haley, 2000)

“My brother has arthritis of the spine. He is in pain and bedridden more than half the time. When he is treated with DMSO, he is able to lead a normal, active life… Just one application of this cheap, safe DMSO changed my brother from a grimacing patient into an active, pain-free man in exactly 30 minutes!” (Haley, 2000)

June Jones, once quarterback and later coach of the Atlanta Falcons pro-football team, had a bursitis calcification in his right shoulder. His career almost didn’t happen as he could hardly lift his arm, let alone throw a football. But he was aware of DMSO and had used DMSO for sprains, like thousands of others. He received a shot of DMSO in the shoulder and after using DMSO for 30 days straight, the calcification disappeared. (Haley, 2000)

 

Stroke

Given soon after a stroke, DMSO can dissolve the clot that causes the stroke, restoring circulation and avoiding paralysis. Once DMSO gets into the body either daubed on the skin, given in I.V., or by mouth, it permeates the body and crosses the brain barrier, so even taken orally it can improve circulation. Ideally it should be I.V.

DMSO products

DMSO is available in various formats.

 

Even though DMSO 40% causes a prolongation of bleeding time, it is still indicated for use in treating embolic or hemorrhagic stroke. DMSO is superior to any other treatment for wounds to the brain where a great deal of bleeding is present (Morton, 1993).

One man who had a stroke at 7:30 AM refused to go to the hospital until after his wife had spoken with Dr. Stanley Jacob, which didn’t happen until 6:30 PM. Starting at 7 PM the day of the stroke, she gave him one ounce of 50% DMSO in a little orange juice every 15 minutes for two hours and then every half hour for two hours. The next day, her husband was better and soon returned to normal. A substance that can stop a stroke as it’s happening is something many might want in their home medicine chest .(Haley, 2000)

Angina, Heart Attacks, Injuries of the Brain and Spinal Chord

DMSO may help neutralize harmful effects on the heart and brain in medical disorders involving the head and spinal chord injury, stroke, memory dysfunction, and ischemic heart disease (Jacob, de la Torre, 2009). A 40% DMSO solution should be administered within four hours to be effective, within ninety minutes is best.

After I.V. administration of DMSO, there is an elevation in the amount of spinal cord blood flow to the region of trauma. One of the first things that happens after spinal cord trauma is that a reduction of oxygen and blood flow sets in, inasmuch as the blood vessels constrict or shut down… Without some treatment, the tissue swells. Eventually, this leads to paralysis. In a cerebral stroke, the animal will either become comatose or lethargic or die. With DMSO infusion immediately after injury (or stroke) all this is prevented. – Dr. Jack de Ia Torre, professor of physiology and neurosurgery at the University of New Mexico

Dr. Stanley Jacob has even given DMSO intravenously to people who were already paralyzed – paraplegics – and some regained use of limbs. One man, quadraplegic, recovered enough to go through college and then to work in a bank. (Haley, 2000)

Infections

When combined with antibiotics, DMSO will convert bacteria which are resistant to a given antibiotic to being sensitive to that same antibiotic and probably a 80 to 90 per cent solution of DMSO will be required in order to be clinically useful ( Pottz, Rampey, Benjamin,1967). DMSO has been used to transport antibiotics to hard-to-reach areas of the body with excellent results, such as the bone marrow and brain (Sanders, 1967).

DMSO can dissolve a virus protein coating, leaving the virus core unprotected with its nucleic acid exposed to the immune system. Applied topically, it alleviates the lesions that occur as a result of Herpes Zoster, shingles (Morton, 1993).
Placed into the nostrils or topically in the face, DMSO can open blocked sinuses within a few minutes and it has been used with sucess in patients with polyps (Marvin, 1967).

DMSO can clear up gum disease and reduce tooth decay and their pain by painting it on the involved areas.

“I have some pharmaceutical grade DMSO and I pour about two teaspoons in a glass in the evening, put my 20 mg of doxycycline in it, add about 2 teaspoons of distilled water, and then swish it around in my mouth for about 2 or 3 minutes and then swallow it. So I guess it is about 50% solution. It’s really working on my mouth. That inflamed area of my jaw has calmed down about 70% in just a couple of days. Or more, actually. I expect it to be completely soothed by tomorrow after tonight’s dose of DMSO.” – Laura, Toulouse, France

Keloids, Scars, Burns, Bruises

A concentration of 50 to 80% put on two or three times a day will flatten a raised scar after several months. It is of considerable value in superficial burns (Goldman, 1967) and when applied quickly to an injury, it can eliminate any bruising.

“I have been applying it to my face for two weeks… I had a bout of acne in March, and this healed the damage pretty well but what amazed me is that my hyperpigmentation (melasma) has also faded very noticeably. In fact, it’s amazing!” – HG, United States

“I diluted a 50% solution and applied it topically to the inflamed lymph node. I applied it again this evening. I am totally amazed! There is a noticeable decrease in the size of the node, in just two applications! And it no longer feels matted. This node has been swollen for over 20 years!!! – Melissa Medlock, Coldwater, Michigan, USA

Podiatry

DMSO can be effective in the treatment of painful corns, calluses, ingrown toenails, bunions, hammertoes, heel spurs, and the inflammation of gouty big toes.

Varicose veins and thrombophlebitis

Topical DMSO can whiten telangiectasias, small dilated blood vessels near the surface of the skin. It can also decrease the size of varicosities in the legs and the inflammation that goes with it, along with a relief of their cramping discomfort (Marvin, 1967. Blumenthal, Fuchs, 1967).

Eye problems

One drop of a 25% DMSO solution (diluted in sterile physiologic or saline solution) once or twice per day is useful for eye problems, including cataracts or glaucoma.

“DMSO is amazing, I’ve also read various good results with using it in the eyes. Being the adventurous type myself, today I diluted DMSO down to 30% and put 2 drops in one of my eyes that has been having red spots around the iris. The red spots diminished drastically. The only side effect was a slight burning sensation, similar to those drops you get when one goes for a glaucoma test, without the side effect of dilated pupils.” – DZ, United States

Headaches

DMSO is highly effective in vascular headaches and in muscular tension which so often goes with headaches. It may be used on hairy areas such as the scalp and it also may be used near the eyes. A 90% solution is more effective (Ogden, 1967).

Mental Disorders

DMSO has been useful in the treatment of patients with the following diagnoses: (1) overexcited states (acute schizophrenic reactions, manic phase of the manic-depressive psychoses, alcoholic psychoses, symptomatic psychoses); (2) some symptoms of the chronic psychoses (autism, stereotypia, negativism, abnormal behavior or delusional states) ; (3) severe neuroses (anxiety reactions, obsessives)( Ramírez, Luza, 1967).

McGrady called special attention to an extraordinary paper presented by Dr. Eduardo Ramirez and Dr. Segisfredo Luza of the Ayetano Heredia University in Lima, Peru. After extensive tests on animals and then on normal humans, Dr. Ramirez reported “injecting 50% or 80% DMSO intramuscularly into patients with acute and chronic schizophrenia” and that “of the 14 acute cases, every single one was discharged from the hospital within 45 days after the start of DMSO treatment… He said that 4 of the 11 chronic cases, one of whom has been ill for 14 years, were discharged eventually, and the other 7 improved a great deal and were given occupational therapy… He observed rapid decrease in agitation… recession of persecution feeling, a relatively sudden tendency to communicate and to stay clean.., the wane of obsessions, return to alertness, and a calmness where there had been restlessness and anxiety”. (Haley, 2000)

Genitourinary disorders

DMSO has been used in the treatment of a number of patients with various genitourinary disorders, including Peyronie’s disease, interstitial cystitis, acute epididymitis. Some have obtained dramatic and gratifying relief of symptoms (Persky, Steeart, 1967).

Miscellaneous

DMSO in conjunction with other treatments has shown to regress cancer in a very effective way (Ayre, 1967). Intravenous administration of DMSO markedly reduces pathological intestinal permeability while preserving the gut’s absorption capacities (Wang et al, 1996). Considering that gut permeability (‘leaky gut’) has a fundamental role in chronic degenerative diseases, this is of great clinical importance.

DMSO also has excellent results in the skin of people afflicted with scleroderma, results which have never been observed with any other method of therapy (Scherbel et al, 1967).

Mrs. Jean Puccio of Washington, DC testified at hearings of Senator Edward Kennedy’s sub-committee on health in 1980 on her recovery from scleroderma. Diagnosed in 1971, she was told that no medication would help, and that she would probably soon face a wheelchair and early death. By the time she found Dr. Jacob (through word of mouth), she told the Senators, “I was having difficulty breathing, walking, and eating”. The disease “thickens the tissue and makes your skin so tight you cannot move. It was difficult for me to drive, to turn the ignition in my car or turn my body”. Her dentist could not work on her for awhile because she could not open her mouth. “Now I can open my mouth like anybody”, she said. After her sensitized skin burned from topical application of DMSO, Dr. Jacob suggested taking it orally. “Within six months”, she testified, “my condition reversed almost immediately. I can do anything anybody else can do now” (Haley, 2000).

Hopefully, this brief overview of DMSO’s great capabilities has helped to illustrate how it is indeed, the cure of our times. I’m convinced of its therapeutic power, both by my own experience and that one of scores of people, not to mention the back-up of published scientific literature. Its uses and applications make it a very handy compound to have on your medical shelf. In pure form, the life of DMSO is indefinite, so it may be used for years.

 

Several books have been published on the benefits of DMSO.

 

Troubleshooting

The garlic-like body odor and taste in the mouth that some experience is attributable to a specific DMSO metabolite: dimethyl sulfide (DMS), a component of natural onion and garlic flavors (McKim, Strub, 2008). This can last for one or two days and in a small number of people, especially men, the odor can be very pungent. Drinking enough water will help diffuse the smell. Other side effects – such as stomach upset, headaches, dizziness, and sedation – are very likely related to detoxification reactions prompted by the DMSO.

Only purified and properly diluted DMSO should be used. When you dilute a pure DMSO solution, always do it in distilled water. When it is applied, the skin site as well as the applying hand should be thoroughly cleaned before application. This is of utmost importance as DMSO’s properties allow contaminants to be absorbed through the skin and transported into the bloodstream.
DMSO is known to be one of the least toxic substances in biology (Parcell, 2002), so any serious side effects should come from potential contaminants or the intake of concomintant drugs that DMSO will carry into the body. Worth repeating again, DMSO and any substance dissolved in it, will penetrate the skin, the blood-brain barrier, and other parts of the body very fast.

Remember also that DMSO increases the effects of drugs like blood thinners, steroids, heart medicines, sedatives, etc. In addition to that, acetone or acid contamination of DMSO can lead to serious medical consequences. Be aware of this problem when buying unreliable DMSO. A pure DMSO solution will turn solid (like ice) in the refigerator within 2 hours. If, when the frozen bottle is turned upside down, little rivulets of water flow through the ice, you probably possess the veterinary grade DMSO. This is a 90% concentration. Ten percent is distilled water (Morton, 1993).

Women are discouraged from using DMSO during pregnancy or breastfeeding, even though DMSO is used to preserve frozen human embryos. DMSO can interfere with liver function tests and give a false reading. That problem is easily solved by waiting a week after DMSO usage before taking the test.

Long-term use has been documented as safe. Eye damage, reported in laboratory animals, has not been confirmed. Side effects such as skin rash and itching after topical application, breaking up of blood elements after intravenous infusion, can be avoided in large part by employing more dilute solutions. Despite these side effects, DMSO is used as a preservative for blood elements and stem cells (McKim, Strub, 2008).

When DMSO is diluted with water, heat is released. The bottle will be warm to the touch. This is a temporary, harmless reaction.
Since DMSO causes dryness and scaling of the outer layer of the skin, skin diseases characterized by scaling (psoriasis) could be aggravated by the use of DMSO. But DMSO applied topically for only a few days has been useful in psoriasis. Prolonged use of DMSO for the treatment of psoriasis is not advised however, as it can worsen the psoriatic condition (Engel, 1967), only DMSO taken orally is suggested.

“I’m happy to say that taking DMSO in conjunction with implementing the detoxification suggestions that were given is starting to take care of many of my remaining psoriasis problems. A couple areas are still being stubborn, but I’ve noticed a lot of general improvement. Using DMSO topically also helped improve a patch of eczema that my wife has been bothered by for quite a while.” – Peter Norquest, Tucson, Arizona, United States

DMSO2, a derivative of DMSO, is better tolerated and doesn’t have the odor and irritation side effects. Despite this positive aspect, it hasn’t surpassed the effectiveness, fascination and popularity of DMSO. It is also known as methylsufonlmethane or MSM, an entire topic for another article by itself!

Sulfur is an element of the earth and it is essential to life, it as among the most prevalent elemenents in the human body. Allergic reactions to sulfur are not possible because sulfur has no protein component. When people are ‘allergic to sulfur’, what they really mean is that they are allergic or sensitive mainly to certain sulfur-containing drugs or proteins, most notably sulfa antibiotics (sulfonamides) or to sulfites (preservatives used in wines and some foods), or to foods with a high sulfur content (broccoli, cauliflower, garlic, onions, etc). Many individuals with allergies to sulfa drugs, sulfites, or high sulfur containing foods (like the author) do not experience problems taking DMSO, because apart from sulfur, DMSO bears no relation to these substances.

As always, proceed with caution, do your homework, and consult a health care provider in case of doubts.

References

Ayre JE, LeGuerrier J. Some (regressive) effects of DMSO dexamethasone upon cervical cells in cervical dysplasia and carcinoma in situ. Ann N Y Acad Sci. 1967 Mar 15;141(1):414-22.
Blumenthal LS, Fuchs M. The clinical use of dimethyl sulfoxide on various headaches, musculoskeletal, and other general medical disorders. Ann N Y Acad Sci. 1967 Mar 15;141(1):572-85.
Engel MF. Indications and contraindications for the use of DMSO in clinical dermatology. Ann N Y Acad Sci. 1967 Mar 15;141(1):638-45.
Goldman J. A brief resume of clinical observations in the treatment of superficial burns, trigeminal neuralgia, acute bursitis, and acute musculo-skeletal trauma with dimethyl sulfoxide. Ann N Y Acad Sci. 1967 Mar 15;141(1):653-4.
Gordon DM. Dimethyl sulfoxide in ophthalmology, with especial reference to possible toxic effects. Ann N Y Acad Sci. 1967 Mar 15;141(1):392-401.
Haley Daniel. Politics in Healing. Potomac Valley Press, 2000.
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Pottz GE, Rampey JH, Benjamin F.Ann- The effect of dimethyl sulfoxide (DMSO) on antibiotic sensitivity of a group of medically important microorganisms: preliminary report. Ann N Y Acad Sci. 1967 Mar 15;141(1):261-72.
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Sams WM Jr. The effects of dimethyl sulfoxide on nerve conduction. Ann N Y Acad Sci. 1967 Mar 15;141(1):242-7.
Sanders M. Discussion. Annals of the New York Academy of Sciences. Volume 141, Biological Actions of Dimethyl Sulfoxide pages 649 – 652, March 1967.
Scherbel AL, McCormack LJ, Layle JK. Further observations on the effect of dimethyl sulfoxide in patients with generalized scleroderma. (Progressive systemic sclerosis). Ann N Y Acad Sci. 1967 Mar 15;141(1):613-29.
Steinberg A. The employment of dimethyl sulfoxide as an antiinflammatory agent and steroid-transporter in diversified clinical diseases. Ann N Y Acad Sci. 1967 Mar 15;141(1):532-50.
Tamblyn R, Berkson L, Dauphinee WD, Gayton D, Grad R, Huang A, Isaac L, McLeod P, Snell L. Unnecessary prescribing of NSAIDs and the management of NSAID-related gastropathy in medical practice. Ann Intern Med. 1997 Sep 15;127(6):429-38.
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Comments

  1. Tiffany Briggs  February 18, 2015

    I am an armwrestler and I want to use DMSO instead of Icy Hot. I have 99.9% gel. How should I dilute it? And can I dilute it with aloe gel?

    reply
    • Gabriela Segura, MD  February 18, 2015

      You can try directly the gel and/or dilute it with aloe vera. Just make sure to use a pure aloe vera solution. You can’t mix DMSO with anything dangerous and/or dubious artificial ingredients.

      reply
    • an  June 28, 2015

      I diluted once my DMSO 99.9% – 16-oz bottle and moved all to a bigger one and ad 5-oz distilled water that’s how you make it safe for using it inside / outside…….

      reply
  2. Rosemary  February 22, 2015

    Good afternoon
    Very interested in your comments regarding DSMO 90, my dog has cyst type swelling between his front toes, vets have tried numerous amounts of antibiotics with no effect. Blood tests, skin biopsy have been taken with results coming back clear. Vet has suggested we have the outer toes removed, this to me is to drastic.
    He is on steroids 25 mg now down to 5 msg per day for his immune system, he has been on these for about 6 months we are reducing the dose down monthly.
    Our last visit to a young vet suggested we try DSMO, which is normally used on horses, as we told her antibiotics had not worked, and we wanted to wean him off the prednisone.
    What does concern us is that when we paint the DSMO90 the wound now bleeds is this normal?
    To be perfectly honest with you we have had the boy for 3 1/2 years and the vet fees during that time have cost about £15,000, his feet are the last straw as every visit is about £ 60.00would really appreciate your comments, is there anything else we can give him with the DSMO

    reply
    • Gabriela Segura, MD  February 23, 2015

      DMSO 90% irritates, so ideally it should be applied around the wound. In addition to DMSO, you can try comfrey root oil topically. Here is a post with excellent ideas as to dietary and alternative treatments for dogs:

      http://www.health-matrix.net/2013/02/18/a-scottish-terrier-miraculous-recovery-from-bladder-cancer/

      Best.

      reply
      • Rosemary  March 15, 2015

        Thank you will give it a try, Rider now loosing his coat, we are so worried about him

      • valerie  March 19, 2015

        Very information article and comments! Can you perhaps recommend me for a dillution and application rate to address a gaglian cyst on my pets ankle. It is not impedding the ankle joint at all but she is active and draining it. It snow about the size of a apricot. Surgery is an option but the skin is tight here and after removal suturing is tricky and the wound is tight subject to tearing open etc. I would like to treat her with dmso. I have 99.9% pure, it is vet grade. Can you recommend a protocol for me? Thank you in advance. All advice greatly appreciated!

      • Gabriela Segura, MD  March 19, 2015

        You can dilute the DMSO with an equal amount of purified water and apply the the DMSO 50% dilution topically once or twice per day. Make sure the pet has enough water around. Best!

      • valerie  March 19, 2015

        opps, I should have proof read my post ! I meant to say, that draining the cyst it is clear fluid, but it just fills right back up again. Also it is growing slowly.

        Thank you! Valerie

  3. Dot Feldman  February 24, 2015

    My sister has pancreatic cancer. How would she take DMSO so that it would help her? She gets chemo and every time her stomach swells and she gets fluid retention. She is in a lot of pain. How could she take this DMSO so that it would work with her chemo and alleviate the pain and swelling?

    reply
    • Gabriela Segura, MD  February 24, 2015

      I’m not sure if DMSO is the best approach, as ideally, a health care provider should assist the process if DMSO is delivered. She can experiment with topical DMSO to see if it relieves the pain. But I think the following research areas could provide more relief:

      Coffee enemas for pancreatic cancer, pain relief and improvements in survival rates
      http://www.coffee-enema.ca/enemasandcolonics.htm

      Alternative remedies in cancer
      http://thetruthaboutcancer.com/

      Diet for cancer cure: Starving cancer ketogenic diet a key to recovery
      http://www.sott.net/article/255022-Diet-for-cancer-cure-Starving-cancer-ketogenic-diet-a-key-to-recovery

      Starving cancer with a ketogenic diet and compressed oxygen: Dominic D’Agostino at TED
      http://www.sott.net/article/289742-Starving-cancer-with-a-ketogenic-diet-and-compressed-oxygen-Dominic-D-Agostino-at-TED

      Ketogenic diet, calorie restriction and hyperbaric treatment offer hope for non-toxic cancer treatment and alleviation of multiple health issues
      http://www.sott.net/article/263446-Ketogenic-diet-calorie-restriction-and-hyperbaric-treatment-offer-hope-for-non-toxic-cancer-treatment-and-alleviation-of-multiple-health-issues

      reply
      • sergio  April 7, 2015

        I am sorry for your sister,
        Cancer is the result of malfunction of the cell, it is a mitochondria problem, that is, when the mitochondria weakens and stops working, the nucleus of the cell (that contais the DNA) “suffocates” because it have no energy to function, than the cell looses control from the body (the extra cell matrix), and searches desperally for FAT. this result in cancer..(of course doctors and Big pharma have another oppinion).

        Than you say: so what???
        All you have to do to CURE, is to restablish mitochondria function. this is done with an chemical messenger called phosfoetanolamine, that your body produces to wake the mitochondria. Than when you restore the energy inside de cell, the nucleus stop searching for energy, and the cell starts functioning again (in reallity, the cell sends a chemical message to the body, that she (the cell) is doomed) The body, then sends a message back to make the cell suicide.. (apoptose). the immune system will than kill the cell and you are cured…

        Theis cheminal messenger (phosfoetanolamine) can be built in syntetic form, not pure but in a form o carbonate, that when eaten (200mg) is send to the liver, the liver than process it and pours it in the blood stream, the cells gethers the product, and make the all mitochondria wake up.. resulting in a kind of “fever” that is the signal of you are bering cured..

        The bad news for you is that this treatment only works if your immuno system is functioning, that is, must not be weaked by chemiotherapy or radiothepapy. and your liver must be functioning, and you must have some FAT

        Another problem is that this “salt” (phosfoetanolamina) is an experimental product made only in Brazil at University of Sao Carlos. costs… nothing.. but you have to go there to get the product.

        There is a video on youtube, look for fosfoetanolamina..

        There is also a book (only one): Natural healing that tells how to use DMSO to cure cancer too, the book is in internet (pdf) it is cheap, you must have some medical and chemical skills to prepare the “potion”… it is DMSO + water + sanguinea extrate (a plant) that when diluted in DMSO (see the proportions in the book) and taken via IV,
        can dissolve the protein shelter that the cancer cells have built to make them invisible to the immuno system.. once the shelter is dissolved, the immuno system can recognize the cancer cells and destroy it…

        Hope it is not too late for your sister…

  4. Tony  March 7, 2015

    Tried dsmo for arthritis pain ok the 1st day second day heart started racing like mad thought I was going to die thought it wasn’t dangerous

    reply
  5. Janice  March 15, 2015

    My husband suffers from Dupuytren’s and he also has pain in the same hand. I want him to try DMSO but he also has liver damage from Hep C. Have there been any studies on DMSO and the liver? He is limited on what he can use for pain relief.

    reply
  6. David  March 18, 2015

    I am a caregiver for my mother who is dealing with Alzheimer’s. I wonder if you have any insight on using DMSO to treat it.

    reply
    • Gabriela Segura, MD  March 18, 2015

      Hello David,

      You can get the DMSO rose cream version and apply it in her temples or wherever you think she might have pain. I highly recommend you get the book “Grain Brain” by neurologist David Perlmutter. There are a lot of things in your hand you can do to improve her quality of life. Best!

      reply
  7. HANAI  March 24, 2015

    Hi I am in Kuwait . from where can I get the MDSO . thank you so much .

    reply
    • Gabriela Segura, MD  March 24, 2015

      Try jacoblab.com or amazon.com. Otherwise through someone you know in the US. Best!

      reply
  8. Penelope  April 10, 2015

    My 19 year old male kitty, Brendan, has been diagnosed as severely hyperthroid 10.0+ (benign tumor in the thyroid enlarging and releasing ever-increasing amounts of thyroid hormone. My vet has prescribed methimazole to be given orally twice daily for the rest of his life. Difficulties with methimazole are given here: http://www.theinternetpetvet.com/hyperthyroidism-cats-safe-effective-holistic-options/

    He also has calcification in some of his joints, for which the vet offers no relief.

    I would like to try using DMSO with him for both conditions. I have DMSO gel and applied it to several of the calcified joints and it had a dramatic effect. I was away for Holy Week and he was being cared for by a friend, but when I returned, he was literally walking with his hind legs on his “tiptoes”. I was shocked and applied the DMSO gel, and by the next day, he was walking and moving normally.

    As I hope to use the DMSO to reduce the thyroid tumor, as well as the calcification in his joints, what would be the optimal form of DMSO and dosage. I used it in his fur and down to the skin. Is that the appropriate mode? Also, mention was maid that the face and neck area are more sensitive to DMSO, so as I hope to treat the thyroid tumor, what modality would be best. I can apply topically, but he is resistant to oral medication.

    Longevity runs in his line as his father, Becket, passed away at the age of 24 on 23rd September, 2014. So, I think Brendan’s prospects for a continued functional and happy life are good if the tumor can be eradicated and his joint calcifiction resolved.

    Thank you so very much for your kind attention.

    reply
    • Gabriela Segura, MD  April 10, 2015

      Hello Penelope,

      One thing that can make the whole difference is diet. Make sure Brendan doesn’t have processed food, but rather a natural diet. Processed foods can age our pets and counteract their longevity genes.

      Fluoride, soy, gluten and other anti-nutrients in processed foods affect the thyroid gland enormously. The same applies to humans. Dietary changes is the one thing that would give Brendan the best results.

      Brendan’s clinical improvement and wellbeing will be the best guide for you, regardless of the lab work and calcification. Symptoms is the best guide. If topical DMSO on joints is having good results, I would keep up with that protocol. I’m glad to hear about the improvement.

      All the best of health for both Brendan and you!

      reply
  9. Sheila  May 1, 2015

    My horse has intermitten swelling in the fetlock from a previous injury. Now they think she has a bone infection which they said there was no cure and she would have to be put down. Would DMSO draw the infection from the bone?

    reply
    • Gabriela Segura, MD  May 2, 2015

      DMSO in combination with antibiotics could help. I would get a second opinion while trying topical DMSO with or without antibiotics.

      reply
  10. Vicky  May 11, 2015

    Hello,

    I live in the UK and have searched high and low for a medic who offers DMSO IV to humans to help treat neuropathy and back problems. Do you know of anyone either inside or outside of the UK who would be happy to preform such a treatment?

    Best wishes,

    Vicky

    reply
  11. kika  May 18, 2015

    Hi, I have a nasty cold sore in my gums, is really painful. I have some dmso 90%, is there some thing I can mix it with to put it right on my gums. Please! and thank you.

    reply
    • Gabriela Segura, MD  May 19, 2015

      I would use a 50% dilution mixed with comfrey root (organic!) and apply topically. Best!

      reply
  12. Carol Van Achter  May 21, 2015

    Could you tell me how I can use DMSO for some decayed teeth that are now quite painful please?

    Many Thanks. Kind regards Carol.

    reply
    • Gabriela Segura, MD  May 21, 2015

      You can mix it with distilled or filtered water and comfrey root (organic). It helps to heal the teeth. Ultimately, checking a dentist might be the best way though.

      reply
  13. Ardy M.  May 29, 2015

    Thanks so much for this post. Does anyone have experience using DMSO for swollen lymph nodes in the neck area? I have several swollen bumps that look like beans sticking out of my neck and they are ruining my self esteem. I was thinking of using DMSO + bay leaf essential oil to paint over these bumps. I’m also taking oral red root tincture several times a day. Any suggestions would be greatly appreciated. Thanks

    reply
    • Gabriela Segura, MD  May 29, 2015

      Sounds like a good plan, but cut out gluten (all grains!) for better results.

      reply
  14. Tanguy  June 5, 2015

    Thank you Dr Segura for all of your articles.

    Is DMSO helping liver to detox?
    I am having digestion problem and it is causing my liver to over work.
    Now the liver is weak, and I am sweating a lot too. ( probably cause by overwhelm liver )
    So Can I use DMSO to help me?

    reply

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