DMSO: The Real Miracle Solution

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Due to the nuclear alert in Japan and its likelihood to affect the United States and other parts of the world, I decided to carry this article which I wrote for the Dot Connector Magazine‘s issue N. 12.

First, a little bit of background.

Radiation produces free-radicals (“inflammatory molecules”) that damage cells that make up tissues such as organs, glands, muscles, and bones. Besides causing the cells to age more quickly they also become distorted, or mutated, creating cancers such as leukemia, anemia, birth defects, and other diseases.

Sulfur has a long history of use as an antidote for acute exposure to radioactive material. DMSO is the classical sulfur compound. A Japanese study showed that even low concentrations of DMSO had radio-protective effects through the facilitation of DNA double-strand break repair, providing protection against radiation damage at all cellular levels in the whole body.

Remember that boosting your body’s detox capabilities and overall anti-oxidants levels is a key to survive in these stressful times. Being on a detox diet is crucial to regain health in a toxic environment. Our extensive experience and research shows that those on a no grain/low carb (no gluten) and non dairy diet fare MUCH better.

For more information on how to protect yourself from nuclear radiation, see:

Treatments for Nuclear Contamination

Iodine Treatments for Radiation Exposure

Greenmedinfo.com – Radioprotective

DMSO is an effective pain killer, blocking nerve conduction fibers that produce pain. It reduces inflammation and swelling by reducing inflammatory chemicals. It improves blood supply to an area of injury by dilating blood vessels and increasing delivery of oxygen and by reducing blood platelet stickiness. It stimulates healing, which is a key to its usefulness in any condition. It is among the most potent free radical scavengers known to man, if not the most potent one.

In 1866, Russian scientist Alexander Saytzeff isolated a most curious and peculiar chemical compound. It was crystalline, odor-less, non-toxic and had a garlic-like taste when consumed. At the time, Saytzeff had no way to predict that his discovery was going to prove highly controversial throughout its entire medical history, that it was going to be tested in thousands of studies, providing miraculous relief in numerous patients.

I’m talking here about dimethyl sulfoxide (DMSO), an organic sulfur compound which was used only as an industrial solvent, that is, until its medical properties were discovered in 1963 by a research team headed by Stanley W. Jacob, MD.
DMSO is a by-product of kraft pulping (the “sulfate process”) which converts wood into wood pulp consisting of almost pure cellulose fibers. As industrial as it may sound, the process simply entails a treatment of wood chips with a mixture of sodium hydroxide and sodium sulfide, known as white liquor, breaking the bonds which link lignin (from the Latin word lignum, meaning wood) to the cellulose.

DMSO is useful as a pain reliever, in burns, acne, arthritis, mental retardation, strokes, amyloidosis, head injury, scleroderma, it soothes toothaches, eases headaches, hemorroids, muscle strains, it prevents paralysis from spinal-chord injuries, it softens scar tissues. In fact, it is useful in well over 300 ailments and it is safe to use. You would think that a compound that has so many alleged uses and benefits will be automatically suspect, but careful examination of its properties and the data available will shed some light in this miraculous chemical.

Sulfur: The Stuff of Life

DMSO is an intermediate product of the global Sulfur Cycle which distributes bioavailable sulfur for all animal and plant life (Parcell, 2002). Sulfur compounds are found in all body cells and are indispensable for life, they are needed for a number of chemical reactions involved in the detoxification of drugs and other harmful toxins, and they have potential clinical applications in the treatment of a number of conditions such as depression, fibromyalgia, arthritis, intersticial cystitis, athletic injuries, congestive heart failure, diabetes, cancer, and AIDS (Parcell, 2002). Among the sulfur compounds, DMSO is probably the one that has the widest range and greatest number of therapeutic applications ever shown for any other single chemical. It has around 40 pharmacological properties that may be beneficial in the prevention, relief or reversal of numerous diseases (Morton, 1993).

Someone complained to Dr. Jacob of a splitting headache and gave him permission to apply some DMSO after hearing of its capabilities. The headache was gone in minutes, came back in four hours, and left for good after DMSO was applied a second time. Used for one purpose, sometimes it did another; put on a cold sore, within a few hours it cleared up a woman’s sinusitis. A woman who had had a stroke found after DMSO was painted on her painful jaw that she could now write with her paralyzed hand and could walk better. (Haley, 2000)

Therapeutic Properties

DMSO is an effective pain killer, blocking nerve conduction fibers that produce pain. It reduces inflammation and swelling by reducing inflammatory chemicals. It improves blood supply to an area of injury by dilating blood vessels and increasing delivery of oxygen and by reducing blood platelet stickiness. It stimulates healing, which is a key to its usefulness in any condition. It is among the most potent free radical scavengers known to man, if not the most potent one. This is a crucial mechanism since some molecules in our bodies produce an unequal number of electrons and the instability of the number causes them to destroy other cells. DMSO hooks on to those molecules and they are then expelled from the body with the DMSO.

 

 


DMSO also penetrates the skin and the blood-brain barrier with ease, penetrating tissues, and entering the bloodstream. Furthermore, DMSO protects the cells from mechanical damage and less of it is needed to achieve results as time passes as oppossed to most pharmaceuticals where increasing doses are required. It has a calming effect in the central nervous system and it reaches all areas of the body, when absorbed through the skin, including the brain. That is, DMSO applied to one area often leads to pain relief in some other location due to its systemic effect.

It acts as a carrier for other substances or drugs and it also potentiates their effect. In fact, certain drugs dissolved in DMSO, such as corticoids, antibiotics and insulin, may be used in a lower dose than usual without reducing their therapeutic efficacy and in addition, their undesirable side effects are greatly diminished. Also, drugs are able to pass through the blood-brain barrier which is usually impenetrable.

DMSO promotes the excretion of urine and functions as a muscle relaxant. It boosts the immune system, increasing the production of white cells and macrophages that destroy foreign material and pathogens in the body. It also has anti-bacterial, anti-viral and anti-fungal properties. DMSO also increases the permeability of cell membranes, allowing a flushing of toxins from the cell.

DMSO has radioprotective properties against lethal and mutagenic effects of X-rays in cells, cellular systems and whole animals. It also has cryoprotective properties, meaning that it is capable of protecting against injury due to freezing.
DMSO has also been shown to have anti-cholinesterase properties (Sams, 1967), in other words, it inhibits an enzyme from breaking down acetylcholine, increasing both the level and duration of action of this important neurotransmitter. Acetylcholine is responsible for learning and memory and is also calming and relaxing. Acetylcholine is also a major factor in regulating the immune system, acting as a major brake on inflammation in the body.

As a source of sulfur, DMSO aids in heavy metal detoxification. Sulfur binds with toxic heavy metals (mercury, lead, aluminum, cadmium, arsenic, nickel) and eliminates them via urination, defecation and sweating.

FDA and Big Pharma Obstacles

DMSO is sold in health food stores, mail-order outlets, on the Internet, and in most countries around the world. It is used by millions for its health benefits yet in the U.S., DMSO has FDA approval only as a preservative of stem cells, bone marrow cells, and organs for transplant, and for interstitial cystitis – a painful inflammatory condition of the bladder which is very difficult to treat with other therapies.

That DMSO has not found favor as a remedy for other medical conditions is partly due to the inability to test it in double-blind experiments. Blind studies, as the name suggests, requires that a study be done without knowing which patient is taking the placebo or the drug. In the case of the DMSO, a blind study is impossible since the peculiar garlic-like taste and smell (no matter the route of application) gives it away and no satisfactory placebo could be devised that would mimic this particular effect of DMSO (Steinberg, 1967).

The FDA and big pharma would prefer we remain dependent on their drugs.


If you search for DMSO on the U.S. National Library of Medicine (pubmed.gov), you’ll get almost 30,000 indexed results, making it one of the most studied compounds of our time. Yet, we are led to believe that DMSO can’t pass the required regulations for its approval in other medical conditions even though its effectiveness and low toxicity profile is unquestionable.

You see, DMSO is a common chemical that can be manufactured cheaply. No drug company can get an exclusive patent since it is also a natural compound, therefore there is no significant financial return. In fact, an executive of a major drug company is quoted as saying, “I don’t care if DMSO is the major drug of our century and we all know it is, it isn’t worth it to us” [CBS TV show 60 minutes with Mike Wallace, The Riddle of DMSO]. If DMSO were to be approved by the FDA, it would be competetive and drug companies would be unable to hold the patents. In the words of the director of the Bureau of Drugs of the FDA, J. Richard Crout, M.D., “DMSO is a low toxicity and safe compound (…) I think that it is a fact of life that drug companies are not going to invest in something unless they think there is some financial return” [CBS TV show 60 minutes with Mike Wallace, The Riddle of DMSO].

Despite restrictions on the use of DMSO, thousands of Americans purchase it on the ‘black market’ each year, its popularity due not to publicity, but rather ‘word of mouth’. When you have something that relieves all kinds of ailments, including some life-threatening ones, people naturally recommend it to friends and family!

In Perspective

In the 1960s, research with DMSO on humans was temporarily halted after certain animals treated with DMSO were found to have changes in the eye lens. Some of these changes resembled those seen in aging dogs (Gordon, 1967), but nevertheless, research was gradually restarted after no evidence was found of eye changes in humans. As Daniel Haley reports in his book Politics in Healing: “Tests in rabbits, dogs, and pigs (but not humans) had shown some problems. When quantities of DMSO equal to about ten times the maximum human dose were given every day over a period of six months, slight changes in the lenses of the animals’ eyes would result, enough to produce a slight nearsightedness. The lens changes were not enough to cause dogs difficulty when running – they didn’t bump into things – and in some cases, the changes disappeared after the massive DMSO doses were stopped. In no test at that time or since has DMSO ever caused cataracts, either in animals or in humans” (Haley, 2000).

In fact, DMSO is effective for macular degeneration and retinal disease, both diseases of the eye. This effectiveness was first discovered when patients with retinitis pigmentosa, a retinal disease, were taking DMSO for certain musculoskeleteal disorders. They sensed that their vision had improved and some had remarkable results (Morton, 1993).

As far as eyes are concerned, the evidence on DMSO is quite to the contrary. When several patients treated with DMSO for muscular problems reported to Dr. Jacob that their vision had improved, he sent them to Dr. Robert O. Hill, ophthalmologist at the University of Oregon Medical School. Confirming the favorable changes, Dr. Hill began his own experiments with DMSO (after it was known that the lens changes did not happen in humans). His research showed drops of 50% DMSO to be effective in retinitis pigmentosa and macular degeneration, and presented a report on this at the New York Academy of Sciences symposium in 1971. (Haley, 2000)

In contrast, the number of medication-related deaths in the U.S. is estimated at over 200,000 a year, making medications the third or fourth leading cause of death (Pezzalla, 2005). Even common pain relievers called NSAIDs, examples of which include Advil, Motrin, Aleve and aspirin, account for an estimated 7,600 deaths and 76,000 hospitalizations in the U.S. every year (Tamblyn et al, 1997). Taking this into consideration, it is safe to declare that DMSO is among the safest substances in the world today. In fact, the classic test for toxicity -the LD-50 test – measures the lethal dose (LD) at which half of a group of test animals is killed. The LD-50 tests for aspirin and DMSO show that aspirin is seven times more toxic than DMSO (Haley, 2000).

Quick Guide and Ailments

DMSO is generally applied to the skin in a gel, cream, or liquid. It can be taken by mouth or as an intravenous injection, in many cases along with other drugs. It has also been administered subcutaneously, intramuscularly, intraperitoneally, intrathecally, by inhalation, instilled into the eye, on the mucous membranes, and into the urinary bladder. Strenghs and dosages vary widely.
If you are just dealing with pain or an injury, use a topical application. Don’t drink it. Drinking it is for serious detoxing and other internal necessities. If you use a rose scented DMSO cream, chances are that nobody will be able to smell DMSO’s garlic-like smell.

DMSO being distilled.

 

The usual oral dose of DMSO is one teaspoon per day of DMSO 70% (Morton, 1993). But since it can trigger detoxification reactions and DMSO’s total excretion from the body can take several days, it is best to do it only once a week. Start with half a teaspoon of DMSO 50% and increase to a teaspoon of DMSO 70% only if any possible detoxification reaction is well tolerated.

When you use liquid DMSO in the skin, let it dry for over 20 to 30 minutes before wiping the rest out. The skin must be clean, dry, and unbroken for any topical use of DMSO. The face and the neck are more sensitive to DMSO and no higher concenrations than 50% should be applied there. Topical concentrations of DMSO should be kept below 70% in areas where there is a reduction of circulation. When 60 to 90% DMSO is applied to the skin, warmth, redness, itching, and somtimes local hives may occur. This usually disappears within a couple of hours and using natural aloe vera, gel or cream, will help counteract or prevent this effect. When 60 to 90% DMSO is applied to the palm on the hand, the skin may wrinkle and stay that way for several days.

“My brother put some DMSO gel (70% dmso, 30% aloe vera) on his shoulders and lower part of neck because he had muscle pain/soreness in that area, and it caused skin redness/irritation for a few hours, although it did diminish the muscle soreness as well…my grandma has rheumatoid arthritis that made her legs swell up and hurt continuously, and I had her apply the same DMSO gel, and after about 2-3 days of applying it once a day, the swelling was 90% gone, and I think within 4-5 days it was 100% gone, and she said the pain diminished as well.” – Michael Shatskiy, Los Angeles, California, United States

Chronic pain patients often have to apply the substance for 6 weeks before a change occurs, but many report relief to a degree that had not been able to obtain from any other source. In general, the greater the chronicity of the disorder, the longer the treatment with DMSO must be employed in order to achieve palliation (Steinberg , 1967).

Common health problems for which people will apply topical DMSO at home include acute musculoskeletal injuries and inflammations. The earlier DMSO is used, the more dramatic the result. A 70% concentration of DMSO mixed with water in volumes ranging from 8 to 12 ml, applied on and around the injury in a wide area at least three times daily, will have a healing affect in 4 out ot 5 people.

Arthritis, Sprains, Strains

It provides rapid amelioriation of pain and increased mobility and reduction of inflammation when used topically. You can see a positive response within 5 to 20 minutes and usually lasting for 4 to 6 hours. (Steinberg, 1967).

“Applying DMSO where it hurt to a six-year-old wasted from rheumatoid arthritis, in a half hour the child could move her shoulder and turn her head for the first time in two years. Persuaded to try walking, she managed a few steps and then burst into tears. “Why are you crying?” Dr Jacob asked her. “Because it doesn’t hurt anymore”, she replied. (Haley, 2000)

“My brother has arthritis of the spine. He is in pain and bedridden more than half the time. When he is treated with DMSO, he is able to lead a normal, active life… Just one application of this cheap, safe DMSO changed my brother from a grimacing patient into an active, pain-free man in exactly 30 minutes!” (Haley, 2000)

June Jones, once quarterback and later coach of the Atlanta Falcons pro-football team, had a bursitis calcification in his right shoulder. His career almost didn’t happen as he could hardly lift his arm, let alone throw a football. But he was aware of DMSO and had used DMSO for sprains, like thousands of others. He received a shot of DMSO in the shoulder and after using DMSO for 30 days straight, the calcification disappeared. (Haley, 2000)

Stroke

Given soon after a stroke, DMSO can dissolve the clot that causes the stroke, restoring circulation and avoiding paralysis. Once DMSO gets into the body either daubed on the skin, given in I.V., or by mouth, it permeates the body and crosses the brain barrier, so even taken orally it can improve circulation. Ideally it should be I.V.

DMSO products

DMSO is available in various formats.

 

Even though DMSO 40% causes a prolongation of bleeding time, it is still indicated for use in treating embolic or hemorrhagic stroke. DMSO is superior to any other treatment for wounds to the brain where a great deal of bleeding is present (Morton, 1993).

One man who had a stroke at 7:30 AM refused to go to the hospital until after his wife had spoken with Dr. Stanley Jacob, which didn’t happen until 6:30 PM. Starting at 7 PM the day of the stroke, she gave him one ounce of 50% DMSO in a little orange juice every 15 minutes for two hours and then every half hour for two hours. The next day, her husband was better and soon returned to normal. A substance that can stop a stroke as it’s happening is something many might want in their home medicine chest .(Haley, 2000)

Angina, Heart Attacks, Injuries of the Brain and Spinal Chord

DMSO may help neutralize harmful effects on the heart and brain in medical disorders involving the head and spinal chord injury, stroke, memory dysfunction, and ischemic heart disease (Jacob, de la Torre, 2009). A 40% DMSO solution should be administered within four hours to be effective, within ninety minutes is best.

After I.V. administration of DMSO, there is an elevation in the amount of spinal cord blood flow to the region of trauma. One of the first things that happens after spinal cord trauma is that a reduction of oxygen and blood flow sets in, inasmuch as the blood vessels constrict or shut down… Without some treatment, the tissue swells. Eventually, this leads to paralysis. In a cerebral stroke, the animal will either become comatose or lethargic or die. With DMSO infusion immediately after injury (or stroke) all this is prevented. – Dr. Jack de Ia Torre, professor of physiology and neurosurgery at the University of New Mexico

Dr. Stanley Jacob has even given DMSO intravenously to people who were already paralyzed – paraplegics – and some regained use of limbs. One man, quadraplegic, recovered enough to go through college and then to work in a bank. (Haley, 2000)

Infections

When combined with antibiotics, DMSO will convert bacteria which are resistant to a given antibiotic to being sensitive to that same antibiotic and probably a 80 to 90 per cent solution of DMSO will be required in order to be clinically useful ( Pottz, Rampey, Benjamin,1967). DMSO has been used to transport antibiotics to hard-to-reach areas of the body with excellent results, such as the bone marrow and brain (Sanders, 1967).

DMSO can dissolve a virus protein coating, leaving the virus core unprotected with its nucleic acid exposed to the immune system. Applied topically, it alleviates the lesions that occur as a result of Herpes Zoster, shingles (Morton, 1993).
Placed into the nostrils or topically in the face, DMSO can open blocked sinuses within a few minutes and it has been used with sucess in patients with polyps (Marvin, 1967).

DMSO can clear up gum disease and reduce tooth decay and their pain by painting it on the involved areas.

“I have some pharmaceutical grade DMSO and I pour about two teaspoons in a glass in the evening, put my 20 mg of doxycycline in it, add about 2 teaspoons of distilled water, and then swish it around in my mouth for about 2 or 3 minutes and then swallow it. So I guess it is about 50% solution. It’s really working on my mouth. That inflamed area of my jaw has calmed down about 70% in just a couple of days. Or more, actually. I expect it to be completely soothed by tomorrow after tonight’s dose of DMSO.” – Laura, Toulouse, France

Keloids, Scars, Burns, Bruises

A concentration of 50 to 80% put on two or three times a day will flatten a raised scar after several months. It is of considerable value in superficial burns (Goldman, 1967) and when applied quickly to an injury, it can eliminate any bruising.

“I have been applying it to my face for two weeks… I had a bout of acne in March, and this healed the damage pretty well but what amazed me is that my hyperpigmentation (melasma) has also faded very noticeably. In fact, it’s amazing!” – HG, United States

“I diluted a 50% solution and applied it topically to the inflamed lymph node. I applied it again this evening. I am totally amazed! There is a noticeable decrease in the size of the node, in just two applications! And it no longer feels matted. This node has been swollen for over 20 years!!! – Melissa Medlock, Coldwater, Michigan, USA

Podiatry

DMSO can be effective in the treatment of painful corns, calluses, ingrown toenails, bunions, hammertoes, heel spurs, and the inflammation of gouty big toes.

Varicose veins and thrombophlebitis

Topical DMSO can whiten telangiectasias, small dilated blood vessels near the surface of the skin. It can also decrease the size of varicosities in the legs and the inflammation that goes with it, along with a relief of their cramping discomfort (Marvin, 1967. Blumenthal, Fuchs, 1967).

Eye problems

One drop of a 25% DMSO solution (diluted in sterile physiologic or saline solution) once or twice per day is useful for eye problems, including cataracts or glaucoma.

“DMSO is amazing, I’ve also read various good results with using it in the eyes. Being the adventurous type myself, today I diluted DMSO down to 30% and put 2 drops in one of my eyes that has been having red spots around the iris. The red spots diminished drastically. The only side effect was a slight burning sensation, similar to those drops you get when one goes for a glaucoma test, without the side effect of dilated pupils.” – DZ, United States

Headaches

DMSO is highly effective in vascular headaches and in muscular tension which so often goes with headaches. It may be used on hairy areas such as the scalp and it also may be used near the eyes. A 90% solution is more effective (Ogden, 1967).

Mental Disorders

DMSO has been useful in the treatment of patients with the following diagnoses: (1) overexcited states (acute schizophrenic reactions, manic phase of the manic-depressive psychoses, alcoholic psychoses, symptomatic psychoses); (2) some symptoms of the chronic psychoses (autism, stereotypia, negativism, abnormal behavior or delusional states) ; (3) severe neuroses (anxiety reactions, obsessives)( Ramírez, Luza, 1967).

McGrady called special attention to an extraordinary paper presented by Dr. Eduardo Ramirez and Dr. Segisfredo Luza of the Ayetano Heredia University in Lima, Peru. After extensive tests on animals and then on normal humans, Dr. Ramirez reported “injecting 50% or 80% DMSO intramuscularly into patients with acute and chronic schizophrenia” and that “of the 14 acute cases, every single one was discharged from the hospital within 45 days after the start of DMSO treatment… He said that 4 of the 11 chronic cases, one of whom has been ill for 14 years, were discharged eventually, and the other 7 improved a great deal and were given occupational therapy… He observed rapid decrease in agitation… recession of persecution feeling, a relatively sudden tendency to communicate and to stay clean.., the wane of obsessions, return to alertness, and a calmness where there had been restlessness and anxiety”. (Haley, 2000)

Genitourinary disorders

DMSO has been used in the treatment of a number of patients with various genitourinary disorders, including Peyronie’s disease, interstitial cystitis, acute epididymitis. Some have obtained dramatic and gratifying relief of symptoms (Persky, Steeart, 1967).

Miscellaneous

DMSO in conjunction with other treatments has shown to regress cancer in a very effective way (Ayre, 1967). Intravenous administration of DMSO markedly reduces pathological intestinal permeability while preserving the gut’s absorption capacities (Wang et al, 1996). Considering that gut permeability (‘leaky gut’) has a fundamental role in chronic degenerative diseases, this is of great clinical importance.

DMSO also has excellent results in the skin of people afflicted with scleroderma, results which have never been observed with any other method of therapy (Scherbel et al, 1967).

Mrs. Jean Puccio of Washington, DC testified at hearings of Senator Edward Kennedy’s sub-committee on health in 1980 on her recovery from scleroderma. Diagnosed in 1971, she was told that no medication would help, and that she would probably soon face a wheelchair and early death. By the time she found Dr. Jacob (through word of mouth), she told the Senators, “I was having difficulty breathing, walking, and eating”. The disease “thickens the tissue and makes your skin so tight you cannot move. It was difficult for me to drive, to turn the ignition in my car or turn my body”. Her dentist could not work on her for awhile because she could not open her mouth. “Now I can open my mouth like anybody”, she said. After her sensitized skin burned from topical application of DMSO, Dr. Jacob suggested taking it orally. “Within six months”, she testified, “my condition reversed almost immediately. I can do anything anybody else can do now” (Haley, 2000).

Hopefully, this brief overview of DMSO’s great capabilities has helped to illustrate how it is indeed, the cure of our times. I’m convinced of its therapeutic power, both by my own experience and that one of scores of people, not to mention the back-up of published scientific literature. Its uses and applications make it a very handy compound to have on your medical shelf. In pure form, the life of DMSO is indefinite, so it may be used for years.

 

Several books have been published on the benefits of DMSO.

 

Troubleshooting

The garlic-like body odor and taste in the mouth that some experience is attributable to a specific DMSO metabolite: dimethyl sulfide (DMS), a component of natural onion and garlic flavors (McKim, Strub, 2008). This can last for one or two days and in a small number of people, especially men, the odor can be very pungent. Drinking enough water will help diffuse the smell. Other side effects – such as stomach upset, headaches, dizziness, and sedation – are very likely related to detoxification reactions prompted by the DMSO.

Only purified and properly diluted DMSO should be used. When you dilute a pure DMSO solution, always do it in distilled water. When it is applied, the skin site as well as the applying hand should be thoroughly cleaned before application. This is of utmost importance as DMSO’s properties allow contaminants to be absorbed through the skin and transported into the bloodstream.
DMSO is known to be one of the least toxic substances in biology (Parcell, 2002), so any serious side effects should come from potential contaminants or the intake of concomintant drugs that DMSO will carry into the body. Worth repeating again, DMSO and any substance dissolved in it, will penetrate the skin, the blood-brain barrier, and other parts of the body very fast.

Remember also that DMSO increases the effects of drugs like blood thinners, steroids, heart medicines, sedatives, etc. In addition to that, acetone or acid contamination of DMSO can lead to serious medical consequences. Be aware of this problem when buying unreliable DMSO. A pure DMSO solution will turn solid (like ice) in the refigerator within 2 hours. If, when the frozen bottle is turned upside down, little rivulets of water flow through the ice, you probably possess the veterinary grade DMSO. This is a 90% concentration. Ten percent is distilled water (Morton, 1993).

Women are discouraged from using DMSO during pregnancy or breastfeeding, even though DMSO is used to preserve frozen human embryos. DMSO can interfere with liver function tests and give a false reading. That problem is easily solved by waiting a week after DMSO usage before taking the test.

Long-term use has been documented as safe. Eye damage, reported in laboratory animals, has not been confirmed. Side effects such as skin rash and itching after topical application, breaking up of blood elements after intravenous infusion, can be avoided in large part by employing more dilute solutions. Despite these side effects, DMSO is used as a preservative for blood elements and stem cells (McKim, Strub, 2008).

When DMSO is diluted with water, heat is released. The bottle will be warm to the touch. This is a temporary, harmless reaction.
Since DMSO causes dryness and scaling of the outer layer of the skin, skin diseases characterized by scaling (psoriasis) could be aggravated by the use of DMSO. But DMSO applied topically for only a few days has been useful in psoriasis. Prolonged use of DMSO for the treatment of psoriasis is not advised however, as it can worsen the psoriatic condition (Engel, 1967), only DMSO taken orally is suggested.

“I’m happy to say that taking DMSO in conjunction with implementing the detoxification suggestions that were given is starting to take care of many of my remaining psoriasis problems. A couple areas are still being stubborn, but I’ve noticed a lot of general improvement. Using DMSO topically also helped improve a patch of eczema that my wife has been bothered by for quite a while.” – Peter Norquest, Tucson, Arizona, United States

DMSO2, a derivative of DMSO, is better tolerated and doesn’t have the odor and irritation side effects. Despite this positive aspect, it hasn’t surpassed the effectiveness, fascination and popularity of DMSO. It is also known as methylsufonlmethane or MSM, an entire topic for another article by itself!

Sulfur is an element of the earth and it is essential to life, it as among the most prevalent elemenents in the human body. Allergic reactions to sulfur are not possible because sulfur has no protein component. When people are ‘allergic to sulfur’, what they really mean is that they are allergic or sensitive mainly to certain sulfur-containing drugs or proteins, most notably sulfa antibiotics (sulfonamides) or to sulfites (preservatives used in wines and some foods), or to foods with a high sulfur content (broccoli, cauliflower, garlic, onions, etc). Many individuals with allergies to sulfa drugs, sulfites, or high sulfur containing foods (like the author) do not experience problems taking DMSO, because apart from sulfur, DMSO bears no relation to these substances.

As always, proceed with caution, do your homework, and consult a health care provider in case of doubts.

References

Ayre JE, LeGuerrier J. Some (regressive) effects of DMSO dexamethasone upon cervical cells in cervical dysplasia and carcinoma in situ. Ann N Y Acad Sci. 1967 Mar 15;141(1):414-22.
Blumenthal LS, Fuchs M. The clinical use of dimethyl sulfoxide on various headaches, musculoskeletal, and other general medical disorders. Ann N Y Acad Sci. 1967 Mar 15;141(1):572-85.
Engel MF. Indications and contraindications for the use of DMSO in clinical dermatology. Ann N Y Acad Sci. 1967 Mar 15;141(1):638-45.
Goldman J. A brief resume of clinical observations in the treatment of superficial burns, trigeminal neuralgia, acute bursitis, and acute musculo-skeletal trauma with dimethyl sulfoxide. Ann N Y Acad Sci. 1967 Mar 15;141(1):653-4.
Gordon DM. Dimethyl sulfoxide in ophthalmology, with especial reference to possible toxic effects. Ann N Y Acad Sci. 1967 Mar 15;141(1):392-401.
Haley Daniel. Politics in Healing. Potomac Valley Press, 2000.
Jacob SW, de la Torre JC. Pharmacology of dimethyl sulfoxide in cardiac and CNS damage. Pharmacol Rep. 2009 Mar-Apr;61(2):225-35.
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Pottz GE, Rampey JH, Benjamin F.Ann- The effect of dimethyl sulfoxide (DMSO) on antibiotic sensitivity of a group of medically important microorganisms: preliminary report. Ann N Y Acad Sci. 1967 Mar 15;141(1):261-72.
Ramírez E, Luza S. Dimethyl sulfoxide in the treatment of mental patients. Ann N Y Acad Sci. 1967 Mar 15;141(1):655-67.
Sams WM Jr. The effects of dimethyl sulfoxide on nerve conduction. Ann N Y Acad Sci. 1967 Mar 15;141(1):242-7.
Sanders M. Discussion. Annals of the New York Academy of Sciences. Volume 141, Biological Actions of Dimethyl Sulfoxide pages 649 – 652, March 1967.
Scherbel AL, McCormack LJ, Layle JK. Further observations on the effect of dimethyl sulfoxide in patients with generalized scleroderma. (Progressive systemic sclerosis). Ann N Y Acad Sci. 1967 Mar 15;141(1):613-29.
Steinberg A. The employment of dimethyl sulfoxide as an antiinflammatory agent and steroid-transporter in diversified clinical diseases. Ann N Y Acad Sci. 1967 Mar 15;141(1):532-50.
Tamblyn R, Berkson L, Dauphinee WD, Gayton D, Grad R, Huang A, Isaac L, McLeod P, Snell L. Unnecessary prescribing of NSAIDs and the management of NSAID-related gastropathy in medical practice. Ann Intern Med. 1997 Sep 15;127(6):429-38.
Walker Morton. DMSO Nature’s Healer. New York: Avery, 1993.
Wang XD, Wang Q, Andersson R, Ihse I. Alterations in intestinal function in acute pancreatitis in an experimental model. Br J Surg. 1996 Nov;83(11):1537-43.

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Comments

  1. Anthony Thomas  May 31, 2016

    Hi there again,
    I have been reading so much about DMSO recently that I am getting a bit confused.
    I live in Thailand where all supplements are difficult to obtain due to the FDA and strict import rules. However I managed to get a bottle of 99.8% DMSO which I have been taking orally to help with the pain in my back, neck etc.
    I think that in the course of all the reading I saw that liquid DMSO is supposed to freeze if you refrigerate it. This worries me as mine did not freeze after 3 hours in the fridge. The bottle was a third used when I tried to see if it would freeze and I seem to recall that when I read about it freezing it stated “An unopened bottle will freeze after 2 hours in the fridge”. This has led to my confusion as mine did not freeze but the bottle was opened before I put it in the fridge with the lid on. Now I am unsure if it is the real thing or not. It tastes foul and seems to be helping with all my pains.
    Sorry to be a nuisance but can you advise me as to whether or not it is real and or if there is any other way to test if it is genuine or not? I am not getting a particularly bad taste or smell of Garlic either but then I consume a lot of Garlic on a daily basis. All I get is a very slightly unpleasant odor in my armpits that my wife only notices if I ask her to check.
    I am also applying 70% DMSO 30% Aloe Vera Gel topically that I get from a different source and that doesn’t seem to make me smell either but they do seem to be helping with the pain.
    Any thoughts?
    Best regards.
    Tommo.

    reply
    • Gabriela Segura, MD  June 2, 2016

      If it is pure DMSO, it freezes on the fridge. If yours doesn’t, maybe it is a lower percentage. You might not smell the DMSO, but your partner should be able to tell the funny smell. Probably you got a much lower DMSO percentage because it does freeze on the fridge if it is pure. It even freezes if the ambient temperature is cold.

      reply
      • Anthony Thomas  June 3, 2016

        Thanks again for your reply.
        The bottle says 99.8%.
        I would imagine that is pure enough to freeze. So maybe the actual DMSO is corrupted. I will talk to the vendor.
        Cheers.
        Tommo.

  2. nadia  June 3, 2016

    Good afternoon Gabriela.
    Congratulation for your research paper.
    Did you have any reference of this work published in an international journal ?
    I would like to cite you in my own scientific work dealing with polymer science and using DMSO as a solvent.
    Thanks !!!!
    Best regards
    Nadia :-)

    reply
    • Gabriela Segura, MD  June 5, 2016

      I recall writing this DMSO article for The Dot Connector Magazine issue #12. Otherwise this link will work. Best of fun with your paper!

      reply
      • nadia  June 6, 2016

        Dear Gabriela,
        Thanks a lot for your answer. Unfortunately, I do not have the opportunity to get this maganzine. (Luckily, you have proposed an on-line version !!!!)
        Can you precise me the references of the corresponding page number dealing with your article in The Dot Connector Magazine issue #12 ?
        Best regards
        Nadia

      • Gabriela Segura, MD  June 6, 2016

        Nadia, I don’t know the pages. I know it is this issue: http://www.redpillpress.com/shop/dot-connector-magazine-12/

        If that doesn’t work, please reference this web article. Best!

      • Peder Sarsten  June 9, 2016

        Thank you Gabriela for your paper on Dmso.I am amazed at the effectiveness of this substance on so many ailments.Antibiotic resistant dis eases can be fought effectively in many cases with the addition of Dmso.The future will prove out its importance.My family and friends are no longer skeptical about using it and thank me because it works so well.

      • Gabriela Segura, MD  June 10, 2016

        Thank you for the testimonial. It is really a wonderful substance.

  3. June  June 14, 2016

    I’m using Dr Stanley Jacobs 70% DMSO which only contains DMSO and water.
    How do I dilute it down to 50%? If I took 10 drops of the 70% DMSO & added 10 drops of water, would that make 50%?
    Thanks

    reply
    • Gabriela Segura, MD  June 14, 2016

      Just add roughly 1/4th of filtered water to your solution, obtaining the desired final amount to be applied to your skin. Best!

      reply
      • June  June 15, 2016

        Many thanks for the answer & the great, informative article!

  4. Chris Mller  June 18, 2016

    Hi,

    Has there been any research in using DMSO for ulcers?

    Thanks

    reply
  5. alan  June 27, 2016

    great for back pain

    reply
  6. Kerri  July 25, 2016

    There was a reference to DMSO helping with melasma when I did the search. Scanning the article, I couldn’t find it. I have Lyme disease and have been working on that for years with the melasma getting worse. We are seeing if heavy metals in my face due to he Lyme disease is what’s causing the melasma. Applying DMSO topically full strength several times a day for a few weeks with no difference, now twice a day with coconut oil. Tried some pure magnesium gel also with it today. Will try anything at this point. Any help/ advise would be great.

    reply
    • Gabriela Segura, MD  July 25, 2016

      It might have been discussed in the comments. For melasma, an autoimmune disease, I would continue to do what you are doing, but I would also see the lugol research. It is known that iodine therapy is excellent for the skin. Check out this post:

      http://health-matrix.net/2015/12/07/iodine-suppressed-knowledge-that-can-change-your-life/

      I don’t know how you are being treated for Lyme’s, but I would not hesitate to do the full antibiotic protocol for 6 months to target stealth infections. Often, autoimmune conditions improve. Adding metronidazol to the protocol at high doses seems to be the trick.

      reply
      • Kerri Outen  August 11, 2016

        I will try this! Thank you for the link. Will let you know if it helps.

  7. Karen Popovich  August 5, 2016

    LOve the article Gabriella, well done! I shared it with several of my patients.
    Just a note: Auto immune disorders respond well to Low Dose Naltrexone. Maybe another article you could write?

    reply
    • Gabriela Segura, MD  August 11, 2016

      Unfortunately, or fortunately depending on the perspective, I never tried LDN. I’ll consider it though. Thank you, Karen!

      reply
  8. Kyle Swart  August 14, 2016

    Hi,

    I read your article on dmso and I am an avid user of dmso. I would like to ask. My wife is pregnant and is battling with back pain. The dmso really helps her but I saw you noted that pregnant or breastfeeding women should avoid dmso. I would like to know why? Does it pose a danger to the fetus?
    Thanks

    reply
    • Gabriela Segura, MD  August 14, 2016

      If I would be pregnant and in pain, I would much rather use DMSO cream in my back rather than take paracetamol. The later one, considered the safest thing to take during pregnancy, has been associated with adverse effects in the newborn.

      The warning is one that I’m passing down from the 1950-1960s research when DMSO was studied in mainstream medicine. There are simply no reliable tests about it in pregnant woman, so it is always best to err in the side of caution.

      reply
      • Kyle Swart  August 15, 2016

        Hi Gabriela

        Thank you so much.

  9. Tina  August 22, 2016

    Hola Gabriela.
    Primero, gracias por el súper informativo artículo. Yo usé DMSO hace unos años, para tratar una tendonitis que tenía en mi codo izquierdo por varios años y este maravilloso liquido simplemente desvaneció el problema. Luego, como pasó un buen tiempo sin que nada me molestara, pues me olvidé del producto, y con ello también olvidé donde conseguirlo. Desde los Estados Unidos tienes alguna recomendación? Quiero ir a lo seguro y conseguir DMSO de verdadera calidad. Me puedes ayudar por favor?
    Gracias! :-)

    reply
    • Gabriela Segura, MD  August 23, 2016

      Me alegra que recuerdes la utilidad del DMSO. Es uno de los productos que continúa siendo inmensamente popular por sus beneficios.

      En EEUU es muchísimo más fácil conseguir el DMSO. Puedes conseguir cualquier formato ilustrado en el artículo en las fotos. El gran favorito de día a día es el DMSO rose cream. No huele mal y ayuda mucho. Para tu kit de emergencias, si conviene que consigas DMSO líquido puro para poder diluirlo según la emergencia con agua fisiológica o filtrada. Por lo general, cualquier DMSO que compres en un sitio web de suplementos o amazon será de calidad aceptablemente buena.

      Un caluroso saludo!

      reply
  10. Chris  August 23, 2016

    I use dmso internal amd external. So many vendors sell this and you never really know what your buying. One vendor says they sell odorless dmso. I bought it and it is oforless, but does this mean it will also lack some
    Of the medcinal properties? The vendor claims if your dmso has a smell its contaminated. Also can it be stored safely in plastic bottles? Some say no others say its ok.

    reply
    • Gabriela Segura, MD  August 23, 2016

      DMSO has a natural and particular smell, so it is not true that if it smells, it is contaminated. In the Spanish section of my site, a reader commented that an odorless DMSO did not had the same effect from the standard DMSO. I don’t have personal experience with the odorless one though.

      reply
      • Chris  September 8, 2016

        The other question I had is from all the reading I Have done on DMSO its extracted from wood pulp, which means its somewhat orgainic in nature. The concern I have is when I contacted several dmso vendors they all state the dmso on the market today is synthetically made. Does
        not seem you can buy it anymore in a natrual form.

  11. Mark Butler  September 3, 2016

    Great overview Gabriela. Given the comment about using it with drugs to increase the effectiveness, what do you think about mixing it with ascorbic acid? Do you think it would increase the absorption rate?

    Thanks
    Mark

    reply
    • Gabriela Segura, MD  September 3, 2016

      I don’t have an experience with that. Although you could try mixing some DMSO cream with liposomal vitamin C as an experiment.

      reply
  12. Tina  September 7, 2016

    So, I got my MSO and just to make sure I got the pure version, I put it in the fridge for 2 hours and it did frizz. The problem I have now is, I took the bottle out and just placed it on the kitchen counter. The sun light doesn’t get to it and the temp in the house is about 72F, but after more than 10 hours there, the DMSO won’t thaw out. Is there a safe way to do it without altering its composition? It is just 8oz of the fluid in a plastic bottle.

    Thanks.

    Tina.

    reply
    • Gabriela Segura, MD  September 7, 2016

      Well Tina, that is some pure DMSO you got there! If the temperature is high enough, it should melt. You can use a heater if necessary.

      reply
  13. Tina  September 7, 2016

    Lol! I meant to say: I got my DMSO. :-)

    reply
  14. Maya Goretsky  September 7, 2016

    Dear Gabriela, many many thanks for your article!
    Not nearly enough educated/and or unbiased info out there and so many questions!
    I own the book “DMSO, the miracle cure” and have been experimenting with DMSO for almost a decade. I’m glad the last comment here was about Vit C, as this is exactly what I prepared tonight, albeit for cosmetic benefit: Since ascorbic acid deteriorates so fast when introduced to water, I’ve decided to see if it’d dissolve in a 99.9% DMSO, which of course it did.
    Why do you recommend to mix DMSO with liposomal C, then? It was going to be my next project, since I wanted to avoid using ethyl alcohol to help dissolve lecithin granules faster for the making of liposomal C. It took a short while, but did dissolve the granules to a lovely paste.
    My burning questions are:
    1.I realize that DMSO won’t help carry and penetrate anything with a molecule that’s larger than it’s own, however since it “loosens” the skin layers (forgive the loose paraphrasing), would it not still help it penetrate to deeper skin layers?
    2. With substances that DMSO successfully carry into the bloodstream, how much of carried substance might remain in the deeper skin layers if any? I realize this is entirely not your field of expertise, but if you could hypothesize, it’d be extremely helpful, as I’ve no way to measure by myself.
    On a small aside, when I mix it with oils and apply to skin, the oils remain on the skin. Either way, the oils greatly reduce if not completely eliminate the stinging I was experiencing before, at as low as 40% DMSO solution.
    Million thanks,

    Maya

    reply
    • Gabriela Segura, MD  September 7, 2016

      I can’t answer your questions with certainty. Your guess would be just as good. Thanks for sharing your experience!

      reply
      • Maya Goretsky  September 7, 2016

        Pity. Could you please elaborate on your recommendation to someone’s previous inquiry try mix DMSO with liposomal C rather than Ascorbic Acid?

  15. Maya Goretsky  September 9, 2016

    I am intrigued about the vit C topic, since it appears that DMSO significantly raises the PH of Ascorbic Acid, the only vit C I’ve experimented with combining with DMSO…Would you agree that DMSO raises Ascorbic Acid’s PH, and if so, why is it? I might be mistaken, as I proceeded adding oil rather than water to the above combo so I might be incorrect.
    I suppose it might be quite ignorant to assume that DMSO raises AA’s PH, due to being rather sweet?

    I hope I’m not annoying you with my inquiries. After all, DMSO is used on burn victims and postoperative healing rate and quality, to merit my fascination with it “cosmetically” speaking.

    many many thanks,

    Maya

    reply
  16. Rick  September 12, 2016

    I dissolve Motrin in a spray bottle of pure DMSO and spray it on pain… I have wrist pain and just today, tore a calf muscle… Heard it rip in fact followed by a whole lot of discomfort… Well I spray this Solution on my calf in my wrist and the pain is substantially, and I mean substantially reduced…!

    reply
    • Frank  September 13, 2016

      Like Rick, I have considered dissolving an NSAD (specifically Naproxen Sodium) in dmso: however, I haven’t because I cannot locate a source for a pure nsaid. Rick, I’m curious, are you using OTC motrin?

      reply
  17. Frank  September 13, 2016

    Gabriela, I hope you don’t mind me raising one other concern: Rick, are you using a plastic spray bottle? And if so, is this plastic spray bottle safe to contain DMSO?

    reply
    • Rick  September 13, 2016

      Well, since my DMSO came in a plastic bottle almost identical to the one I’m using as a spray bottle, I’m going to assume that it safe and yes it’s very effective, what I’m doing I tore a calf muscle… Took some Motrin dissolve them in the DMSO spray bottle sprayed it on wrapped it with an Ace bandage 85 and 90% of the pain gone… I have sworn by this stuff for years

      reply
      • Frank  September 14, 2016

        Rick, DMSO is NOT compatible with ALL types of plastic. It is not safe to simply assume that (because it came in a plastic bottle) that the bottle you have is also made of a compatible plastic. I am glad that you haven’t noticed any ill effects yet from the other ingredients in your motrin and from (possibly) absorbed plastc.

        Gabriela, can you point me to a source for pharmaceutical grade naproxen sodium? Thanks!

      • Gabriela Segura, MD  September 14, 2016

        Any naproxen should be pharmaceutical grade. You can check with the provider for purity. Best!

  18. Tommo  September 15, 2016

    Hi there, this may seem like a strange question but does DMSO dissolve Silicone?
    I ask because my wife has Silicone breast implants and I have Silicone lenses in my eyes.
    I have been taking DMSO orally for a few months now and just began having IV drips with it.
    I have researched it for a while now and even asked Drs who use it but cannons get an answer.
    As always your reply will be appreciated.
    Thank you.

    reply
  19. Karen Popovich  September 23, 2016

    Hi Gabriela,
    Just to tell everyone I used DMSO yesterday on a severe finger burn and it was amazing. I diluted it in a glass and put my fingers in and had immediate relief, but continued for 30 minutes on/off and this morning, no blister, able to work…Happy. I also use it for a horse who has chronic allergy to dust and couldn’t breathe well, I dissolved regular Vit C, “Magnesium chloride oil”, NAC and MSM in the DMSO and it has helped her breathing back to normal. For the nasal passages we dissolved a weak DMSO solution with Ionic silver and into her nostrils: immediate improvements in breathing and releasing of mucus plugs.

    reply
  20. fred  September 25, 2016

    Gabriella,

    did you run across any information specifically related to Peyronies disease and how DSMO is used? I have seen topically but those that have used it and spoke of it on the forums have not noticed big improvement. I’m wondering whether subcutaneous applications around the placing site would be safe if diluted. I’ve searched the internet and not a lot about this. Do you have some resources that you can think of that might help answer this? or do you think it’s safe to do a trial and error with that? i do vitb12 injections so I would be okay trying just don’t know what to dilute the solution with? saline? or distilled water?

    reply
    • Gabriela Segura, MD  September 25, 2016

      I received the same exact inquiry earlier this year. Wasn’t it you? In any case, if you are going to take the responsibility of experimenting with DMSO upon yourself, then always start with the lowest dilution possible. Parenteral DMSO ranges widely, but a 20% dilution has been used safely. You can even go much lower than that and increase gradually if necessary. For injections, only physiological solution or sterile saline solution is acceptable.

      reply

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