Intravenous DMSO – Unsurpassable Results in Clinical Practice

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There has been some pretty fascinating studies published during the last decade which illustrate the miraculous effects of DMSO in a population that otherwise had no hope, namely cancer patients in palliative care.

For instance, intravenous DMSO was used to relieve pain in advanced biliary cancer and not only did it achieved that, but regression of major signs and symptoms including liver damage and enlarged organs were also reported. You cannot really appreciate the implications of this from the abstract alone. In fact, it would be a practical impossibility to surpass the positive effects this research group achieved considering the extent and the type of cancer. So let’s have a closer look.

Palliative Treatment for Advanced Biliary Adenocarcinomas With Combination Dimethyl Sulfoxide–Sodium Bicarbonate Infusion and S-Adenosyl-L-Methionine” by Ba X. Hoang, Hung Q. Tran, Ut V. Vu, Quynh T. Pham, and D. Graeme Shaw reports:

Pretty remarkable I would say! Someone had a great idea to make the conversions to Western available units, i.e. sodium bicarbonate 8.4%:Here’s a conversion to Western available units, i.e. sodium bicarbonate 8.4%:

I was surprised to learn that the best research available on parenteral DMSO was from veterinary medicine. See for instance, Dimethyl Sulfoxide (DMSO) – A Review by Cory Flagg Brayton published in The Cornell Veterinarian. v.76 1986.

In this update from pioneer Stanley Jacob and his colleague Jack de la Torre, “Pharmacology of dimethyl sulfoxide in cardiac and CNS damage” (2009), DMSO’s benefits are summarized as follows:

They also report how to use DMSO IV safely. For spinal cord injuries, they recommend a dose of 1-2g/kg in a 28-40% solution of DMSO diluted with either physiological solution or 5% dextrose with water in an IV. However, to prevent DMSO-induced intravascular hemolysis (a reversible temporary side effect where red blood cells are lysed), it is recommended to use a less than 30% DMSO solution in an IV. However, water retention and hypernatremia has been reported with high DMSO dilutions, for instance < 10% in severe head trauma patients.  This side effect can be avoided when a 25-35% DMSO solution is given in an IV.

The DMSO infusions and cocktails are the personal favorites in my personal practice with family and extended family. It has saved loved ones from dire emergencies as well, i.e. post-traumatic brain injury edema. Here’s a sample of how I’ve used it, with doses variating according to weight and condition. The infusion rate is approximately 1 drop per second:

Nacl 500ml
Vit C 20gr-25g (40ml-50ml)
DMSO 6ml-15ml
B1 100mg
B6 100mg
B12 1000mcg
Folic acid 20mg (2ml)
MgCl 1g (10ml)
Glutathione 300mg (5ml)
Actovegin 200mg-400mg (5ml-10ml)


In regards to Hoang formula, the conversion to Western units is really the following for 25ml of DMSO:

83 ml 8.4% Sodium Bicarbonate

392 ml Sterile Water or Ringer Lactate or Physiological Solution

25 ml 99% DMSO

Further reading

DMSO: The Real Miracle Solution

Dimethyl Sulphoxide (DMSO) in Trauma and Disease by Stanley W. Jacob and Jack de la Torre

DMSO: Nature’s Healer by Morton Walker

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  1. Paul  November 8, 2019

    Great Read!!!

    thoughts on oral DMSO?

    • Gabriela Segura, MD  November 8, 2019

      I think it has its applications. Pain relief has been described with oral, topical and parenteral DMSO. So yeah, it’s good to keep in mind.

  2. Lonie Nicholas  December 19, 2019

    I’m a 69 years (and 70 months) of age male with a goal of setting a record for longevity. I am concerned that my skin may not age as well as my over-all self.

    I am currently experimenting with applying distilled water with GDF 11 and DMSO added. GDF-11 is a large molecule, so I’m hoping the DMSO will somehow manage to get it through my epidermis into my dermis, and hopefully beyond into the subcutaneous region.

    Am I on a Fool’s Errand or the right track?

    • Gabriela Segura, MD  December 19, 2019

      Let us know how it goes!

    • Mel Banman  January 27, 2020

      I’m currently taking DMSO and have for 3 yrs. I started taking Borax/Boron with DMSO to help with integrity and function of cell walls. Website below is where I got my information from that led me to think this would be an ultimate combination to heal my body. It is currently helping me heal tumors on my feet where DMSO alone could only stablilize them. Let me know if this helps you too.

  3. Sean E  November 2, 2021

    What does it mean when a % of DMSO is given when referring to an IV infusion? For example , 30% DMSO solution should be used ….?? Why aren’t the calculations always using 99.9% DMSO? It’s diluted in the IV bag. I can’t wrap my head around the % that I often encounter when reading about DMSO. Please advise. Thanks. I e always thought that 1g / kg of body weight of DMSO was referring to the 99.9% DMSO. Why use the %. ? Thanks!!


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